Research Progress on the Mechanism of Action of circRNA in Osteosarcopenia
LIU Ling1, DENG Xiaozheng2, ZHANG Ting1, GAO Xuebin1, ZHANG Jianping1 *
OS (osteosarcopenia) is a metabolic disease that primarily affects the musculoskeletal system, characterized by a simultaneous decrease in muscle mass, function, and bone density, strength. Due to its more severe adverse health outcomes and higher disability and mortality rates compared to SP (sarcopenia) or OP (osteoporosis) occurring alone, OS has posed a huge threat to the health and public health safety of middle-aged and elderly people worldwide. However, the difficulty of OS treatment lies in balancing muscle and bone simultaneously. At present, apart from exercise therapy and nutritional support, there is a lack of effective therapies that can simultaneously reverse SP and OP. circRNA (circular RNA) is a type of circular non coding RNA molecule that plays an important role in gene regulation in many cells. Recent studies have found that circRNA is also involved in various biological processes and pathological mechanisms of muscle bone decay disease, which is expected to become a new direction for studying OS.
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