Research Progress of Exercise in Prevention and Treatment of Parkinson’s Disease by Regulating BDNF/TrkB Pathway

ZHOU Wenhui^1
*, LI Gangqiang²

( ¹ Changde Vocational and Technical College, Changde 415000, China; ² School of Foreign Affairs, Central South University of Forestry and Science, Changsha 410000, China)

Abstract:

PD (Parkinson’s disease) is a chronic progressive neurological disorder. Dysregulation of BDNF (brain-derived neurotrophic factor)/TrkB (tyrosine kinase receptor B) signaling pathway is associated with PD development. Regulation of the BDNF/TrkB signaling pathway has been suggested as a therapeutic strategy in PD. Exercise therapy is a non-toxic, low-cost and generally applicable non-pharmacological treatment that not only reduces the risk of PD, but also has a positive effect in improving PD-related behavioral dysfunction, and its mechanism may be achieved by regulating the BDNF/TrkB signaling pathway. This article reviews the possible role of BDNF/TrkB pathway in the occurrence and development of PD and the prevention and treatment of PD exercise.

CSTR: 32200.14.cjcb.2025.02.0016