Research Progress on the Mechanism of Macrophage-Tumor Ferroptosis Interaction Network
LIU Fang1#, MA Xiaoxia1#, FAN Tingting1, TIAN Yu2, LIU Qinglin1, CHEN Che1 *
Tumor associated macrophages, as the main component of the tumor microenvironment, are closely related to the malignant progression of tumors. They have functions such as regulating metabolism, engulfing pathogens and dead cells, mediating inflammatory responses, and promoting tissue repair. Ferroptosis is a novel form of grammed cell death that is dependent on iron and plays an important role in tumors. Due to the similarity between the function of macrophages and the behavior of ferroptosis, there must be an interaction between the occurrence of ferroptosis and the state of macrophages. So far, the relationship between ferroptosis and macrophages has been applied to study the treatment of various diseases, especially cancer, which can provide new targets for people to better understand the pathological process and treatment of tumors. This article mainly introduces the mutual influence relationship between different polarization of macrophages and tumor ferroptosis, and reviews the important applications of changing macrophage polarization status to treat tumor ferroptosis.
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