The Mechanism and Rehabilitation Strategy of High Mobility Group Protein B1 in Children Spinal Cord Injury
CAO Qi*
CSCI (childhood spinal cord injury) refers to the abnormal structural changes and functional damage of the spinal cord in children under 14 years old due to various reasons, which may lead to the loss or abnormality of motor, sensory, and autonomic nervous system function, and can cause serious adverse outcomes for pediatric patients. Due to the irreversibility of spinal cord injury, there is currently no strategy in the medical community to cure CSCI, so rehabilitation treatment for CSCI is particularly important. HMGB1 (high mobility group protein B1), as an important inflammatory mediator, plays a crucial role in the pathological and physiological processes after spinal cord injury. Due to its unique physiological background and developmental stage, compared with adult, childhood spinal cord injury have different responses to HMGB1. Therefore, it is particularly important to explore its mechanism of action in depth. This article provides an overview of the basic properties and functions of HMGB1, and elaborates on the expression patterns of HMGB1 after CSCI and its mechanisms in pathological processes such as nerve injury, inflammatory response, and cell apoptosis. This article explores relevant rehabilitation therapy strategies for the mechanism of HMGB1, providing new ideas and methods for disease management in CSCI.
CN
EN