Study on the Mechanism of CYLD in Tumor-Related Signaling Pathway
BAN Bingbing, WEI Cheng, WANG Cheng*
Members of the deubiquitinating enzyme family are involved in the regulation of a variety of cellular signal transduction and metabolic processes, and their aberrant expression or altered activity is closely related to the development of tumors and other diseases. The tumor suppressor CYLD (cylindromatosis) is lowly expressed in a variety of tumors and is a member of the deubiquitinating enzyme family. It can remove the ubiquitin chain on specific proteins, regulate various intracellular signaling pathways such as NF-κB, Wnt, JNK and so on, and affect the processes of cell growth, differentiation and apoptosis, and its aberrant expression has been associated with a variety of cancers and hereditary diseases. In recent years, a large number of studies on the mode of action of CYLD in the progression of various tumors have been reported, and this article provides an overview of the study of CYLD in the main relevant signaling pathways and its effects on tumors.
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