Advances in Non-Coding RNA Mechanisms of Mechanical Loading Regulating Bone Formation
WANG Qian, LIN Junbin, XIA Lu*
Bone tissue, as a mechanically responsive tissue, is able to respond to stimulation by mechanical loading. Mechanical loading can affect bone formation and resorption by regulating complex intracellular signaling. Studies have shown that ncRNA (non-coding RNA) plays an important role in the regulation of bone formation and resorption by mechanical loading. Among them, lncRNA (long non-coding RNA), miRNA and other ncRNAs are involved in the regulation of various pathways in a synergistic manner, which in turn are involved in the regulation of bone formation under mechanical loading conditions. This papersummarized the key ncRNAs and their pathways involved in the regulation of mechanical loading, aiming to clarify the specific intrinsic mechanism by which mechanical loading regulates bone formation through the modulation of ncRNAs, which provides a theoretical basis for the further application of mechanical loading to promote osteogenic differentiation, as well as a reference for the treatment of diseases related to abnormalities in bone formation.
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