Progress on the Role of Striatal A_2AR in the Prevention and Treatment of Parkinson’s Disease by Exercise

A_2AR (adenosine 2A receptor) is specifically expressed in neurons of the striatal indirect pathway and plays an important “integrated” role in the regulation of striatal-dependent programmed behavior. Excessive activation of the indirect pathway under PD (Parkinson’s disease) pathology is associated with A_2AR overexpression in the striatum. However, A_2AR-specific antagonists have unique cognitive-promoting functions and neuroprotective effects while improving dyskinesia in PD patients. Various types of exercise therapy have received increasing attention for their positive effects in improving PD-related behavioral dysfunction, which show positive effects in neuroprotection, anti-inflammation, anti-oxidative stress, regulating neurotransmitter expression in the central nervous system and promoting neuroplasticity, and can significantly affect striatal A_2AR  expression levels. Starting with A_2AR, this paper elaborates the possible role of A_2AR in the prevention and treatment of PD neurodegeneration and PD movement, providing a theoretical basis for the development of new targeted drugs for PD and the study of neurobiological mechanisms, and providing a reference for the improvement and promotion of non-invasive physical therapy.

CSTR: 32200.14.cjcb.2024.12.0012