Research Progress of Tim-3 in Autoimmune Diseases
WU Jialong, HUANG Biao, ZHOU Xiumei*
Autoimmune diseases are a series of diseases caused by the immune system mistakenly attacking its own tissues or organs, which are related to the excessive activation of immune cells. Tim-3 (T cell immunoglobulin and mucin domain-containing protein-3) is an immune checkpoint molecule. It can regulate the function of immune cells by binding to different ligands, and play an immunomodulatory role in autoimmune diseases. This review summarizes the structure and biological function of Tim-3, the interaction between Tim-3 and different ligands, and the research progress of Tim-3 in autoimmune diseases. The prospect of Tim-3 as a target for immunotherapy is discussed, which provides new ideas for the application of Tim-3 in autoimmune diseases
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