Advances in the Relationship between PLAC and Placenta-Mediated Pregnancy Disorders
LI Lianchun1, ZHU Zhenyi1, YANG Hao1, YANG Yongkang2*, LI Qin2*
PLAC (placenta-specific family protein) is a class of placenta-specific expressed protein that promote placental and fetal growth and development, and ensure the smooth progression of pregnancy by regulating placental formation, embryo implantation, and the function of trophoblast and embryonic stem cells. In recent years, more and more attention has been paid to the changes in expression of PLAC family protein in placenta-mediated pregnancy disorders, with significant differences between them and healthy pregnant women, and abnormalities in the expression of related proteins and genes that may be associated with the risk of placental dysfunction and disease development. It is important to explore the relationship and mechanism of action of PLAC family protein with placenta-mediated pregnancy disorders, and they may be potential biomarkers for pregnancy disorders, which are expected to be used for diagnosis and prevention of diseases.
CN
EN