Myelin Regeneration Strategy for Multiple Sclerosis Based on Microenvironment Regulation

JIN Shuqi¹, LUO Fucheng¹, CUI Jianchen^1,2,3*

(¹State Key Laboratory of Primate Biomedical Research, Institute of Primate Translational Medicine, Kunming University of Science and Technology, Kunming 650500, China;²Department of Anesthesiology, First People’s Hospital of Yunnan Province, Kunming 650032, China;³Department of Anesthesiology, Affiliated Hospital of Kunming University of Science and Technology, Kunming 650032, China)

Abstract:

MS (multiple sclerosis) is an inflammatory demyelinating disease caused by the immune system attacking the myelin sheath. Myelin regeneration is crucial for the recovery of nerve function, but in MS patients, this process is often hindered. As the influence of the microenvironment on myelin regeneration is gradually revealed, researchers begin to pay attention to its mechanism of action in MS. Understanding and regulating the microenvironment in MS may provide new ideas for developing new treatment strategies. This article summarizes the research progress in the microenvironment regulation of myelin regeneration and discusses how different microenvironmental factors affect myelin regeneration and its potential significance for future MS treatment.

CSTR: 32200.14.cjcb.2024.11.0013