Research Progress on the Mechanism of Action and Intervention Strategies of Heat Shock Proteins in Rectal Cancer
BI Xinran1,2#, MA Yuqi1,2#, ZHAO Shuangyan1,2#, DUAN Xiaoyu2, FU Yawen1,2, ZHANG Yisu1,2, HU Tingting2*, CAI Hongyi2
HSPs (heat shock proteins) are a class of proteins that are highly expressed under cellular stress. In tumor cells, the high metabolic activity, rapid growth, and unstable intracellular environment can significantly increase the expression level of HSPs. Research has shown that HSPs play an important role in the occurrence, development, and treatment of rectal cancer. HSPs play an important role in the proliferation, metastasis, and drug resistance of rectal cancer cells. Therefore, HSPs also have potential utilization value in the treatment of rectal cancer. By interfering with the expression or function of HSPs, the proliferation, migration, and drug resistance of rectal cancer cells can be effectively inhibited, while enhancing the efficacy of chemotherapy and radiotherapy for rectal cancer. In addition, the expression of HSPs is closely related to the malignancy and prognosis of rectal cancer, and can serve as a biomarker for the diagnosis and prognosis evaluation of rectal cancer. Therefore, further in-depthresearch on the detailed mechanism of HSPs in rectal cancer can help provide more effective strategies for the treatment and management of rectal cancer. Meanwhile, utilizing HSPs as biomarkers for rectal cancer is expected to provide new methods and tools for the diagnosis, prediction, and prognosis evaluation of patients.
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