Research Progress on the Anti Phage Function of Prokaryotic Ago
LIANG Jiamin1,2, ZHEN Xiangkai1,2, OUYANG Songying1,2*
Ago (Argonaute) is a protein family widely present in various organisms. In eukaryotic organ isms, Ago is the core component of silencing complexes in RNAi (RNA interference) processes. It is an RNA endonuclease guided by a small RNA (21 nt in length) that specifically degrades its paired RNA. In prokaryotes, there are numerous Agos, compared to eAgo (eukaryotic Ago), pAgo (prokaryotic Ago) exhibits diversity, but there is a lack of research on its functions. Recent studies have found that short pAgo, which accounts for the majority of pAgo, can exert its anti-phage function in various ways. This article summarizes recent research regarding anti phage functios and molecular mechanisms of short pAgo, providing reference value for the functional research of other short pAgo.
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