Research Progress on the Relationship between SIRT2 and Cardiovascular Disease

XIONG Yulian^1,2, DU Yanhuan^1,2, ZHANG Shizhong^1,2*

(¹Basic Medical College of China Three Gorges University, Yichang 443000, China; ²Third-Grade Pharmacological Laboratory on Chinese Medicine, State Administration of Traditional Chinese Medicine, China Three Gorges University, Yichang 443000, China)

Abstract:

As a long-lived protein, SIRT2 (silent information regulator 2) is a member of the silent infor mation regulator family and a deacetylase dependent on NAD+ (nicotinamide adenine dinucleotide). In recent years, a growing body of research has confirmed the involvement of SIRT2 in the development of cardiovascular diseases, and the structure and function of SIRT2 have been gradually established to be associated with cardiovascular-relat ed diseases. This article mainly reviews the key role of SIRT2 in regulating the biological effects of the organism, elucidates its intrinsic mechanism in cardiovascular-related diseases such as atherosclerosis, myocardial ischemia reperfusion injury, myocardial infarction, and heart failure, and summarizes the current research progress on SIRT2 related agonists and inhibitors, which will provide a new way of thinking to search for the potential therapeutic targets of cardiovascular diseases.

CSTR: 32200.14.cjcb.2024.10.0010