Advances in Inhibitors of Membrane Fusion of Coronavirus
WU Xinrui1, GUO Zhongwei1, HUANG Yong1, CUI Min1, XIA Jing1,2*
Coronaviruses are a type of enveloped RNA viruses that commonly infect humans and animals. They are known for their high transmissibility and pathogenicity, and can cause severe clinical symptoms and death. Developing specific medications is an effective strategy for controling coronavirus infection. The membrane fusion process plays a crucial role in the viral entry into target cells, and it is also a common target for specific medications. Drugs specifically targeting membrane fusion in animal coronaviruses are still in the research and development phase, while some drugs for human coronaviruses are already in clinical use. These medications pri marily consist of peptides, small molecule and proteins, and some methods to improve the inhibitory effect of drugs are being actively developed. This review introduces various types of inhibitors that target different stages of the membrane fusion process in coronavirus, discussing their advantages, disadvantages and future potential to provide reference for the treatment and control of coronavirus.
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