The Improvement of Brain Functions via Post-Translational Modification of Proteins by Exercise Mediated Metabolic Homeostasis
ZHANG Li*
Different types of exercise training significantly affect the body metabolic homeostasis. The exercise-related metabolites act as the energy supply molecules and have profound effects on intracellular signal ing pathways. In particular, the process of PTM (post-translational modification) of proteins is highly dependent on exercise-mediated metabolites such as acetyl, lactate, fatty acid and monoamines. It is thus proposed that exer cise training may affect PTM in brain proteins, thus modifying synaptic and neural network activities, for improv ing brain functions such as mental or cognition. Focusing on this specific field, studies have already revealed the mechanism of lactate molecules in modulating synaptic protein lactylation under exercise training, thus implying the potential metabolic-brain axis in exercise-mediated improvement of mental disorders. In future, one can deploy research to reveal the correlation between exercise training load and the effect of protein modifications, to identify more PTM of brain proteins at the downstream of exercise-related metabolites, and to establish a complete picture between whole body metabolic homeostasis and brain protein modification. These works add more knowledge on the peripheral-central pathway of exercise in improving brain health and facilitate the promotion of exercise inter vention of brain diseases, or the future development of exercise mimics.
CN
EN