Research Progress of NLRP3 Inflammasome in Obesity and Its Related Metabolic Syndromes
WANG Zhe, SUN Cheng*
As a new form of cell programmed cell death, pyroptosis plays an important role in many dis eases. In recent years, the relationship between pyroptosis and obesity and its related metabolic syndromes receives much more attention. A large number of studies have shown that NLRP3 inflammasome-mediated pyroptosis can affect the progression of obesity and its related metabolic syndromes. Therefore, the NLRP3 inflammasome is a promising target with great therapeutic potential for treating obesity and its associated diseases. In this article, f irstly the molecular mechanism of NLRP3 inflammasome mediated pyroptosis was described. Secondly, this article discussed the latest advances in NLRP3 inflammasome in obesity and its related metabolic syndromes. Finally, a number of drugs and formulations with targeted inhibition of NLRP3 inflammasome activation are listed, which may lead to more options and benefits for preventing and/or treating obesity and related metabolic syndromes.
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