Research Advances in Host Cell Cycle Regulation by Cyclomodulins
CHEN Shuyue1, OUYANG Songying1,2, GUAN Hongxin1*
Highly regulated cell cycles are generally found in eukaryotic cells and play a key role in con trolling important life processes such as cell growth, division, genetic processes, cell proliferation, etc. During infection of a host, cell cycle regulation by the bacterium is critical for its invasion, colonization, replication, and spread. Bacterial cell cycle regulatory proteins, cyclomodulins, are primarily tools used by bacteria to regulate the host cell cycle, including bacterial toxins or effector proteins. This review summarizes the impact of the host cell cycle on bacterial infection and reviews the regulatory mechanisms of classical and recently reported cyclomodu lins. This review will provide insight into the critical role of cyclomodulins in the process of bacterial infection of the host.
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