Research Progress of Cuproptosis in Hepatocellular Carcinoma
HUANG Yuan1, SU Yazhen1, WANG Changrong1, GUAN Yongyu2, LIU Fang1, CHEN Che1*
Cuproptosis is a newly discovered copper-dependent form of programmed cell death related to mitochondrial respiration. Excessive copper leads to cell death by interfering with mitochondrial tricarboxylic acid cycle and triggering protein toxic stress. Copper metabolism and cuproptosis are closely related to the occurrence and development of tumors. The liver is the main organ in the body where copper is stored and excreted. Inducing cuproptosis in hepatocellular carcinoma cells is a promising therapeutic approach, and exploring the relationship between cuproptosis and hepatocellular carcinoma is helpful to find new and effective therapeutic strategies. There fore, this paper discusses the correlation between cuproptosis and the occurrence, development and prognosis of he patocellular carcinoma, and summarizes the therapeutic methods of hepatocellular carcinoma related to cuproptosis, in order to provide references for the diagnosis, treatment and research of hepatocellular carcinoma.
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