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Home > Browse Issues > Vol.46 No.9

Preclinical Research Progress of Wound Healing Treated by Multiple Exosomes


TENG Yongxiang1,2, SU Gang1, LI Zhaoxin3, ZHAI Zhaohui4, LI Yuli5, CHEN Yuanzheng6*

(1School of Clinical Medicine, Shandong Second Medical University, Weifang 261053, China;2Department of Burn and Plastic Surgery, Linyi People’s Hospital, Shandong Second Medical University, Linyi 276002, China;3Weifang Hospital of Traditional Chinese Medicine, Shandong Second Medical Universityy, Weifang 261053, China;4Institution of Plastic Surgery, Shandong Second Medical University, Weifang 261053, China; 5School of Rehabilitation Sciences and Engineering, University of Health and Rehabilitation Sciences, Qingdao 266071, China;6Department of Burn and Plastic Surgery, Emergency General Hospital, Beijing 100028, China)
Abstract:

Chronic refractory wound is a major public health problem in the world. The healing process in volves a series of overlapping space and time stages, and its process is complex and diverse. For the use of existing clinical treatment of chronic refractory wounds that are difficult to heal, there is an urgent need to find a new treat ment. The exosomes secreted by stem cells can play a role in multiple stages of wound healing, showing a unique advantage in the treatment of chronic refractory wounds. Exosomes is a new type of intercellular communication carrier that regulates the biological behavior of skin cells. It widely exists in a variety of body fluids and has the advantages of non-immunoreactivity, tumorigenicity and good biocompatibility. It mainly comes from adipose derived stem cells, bone marrow-derived stem cells, human umbilical cord stem cells and other types of stem cells. Different types of exosomes have different functions and play different roles in wound healing according to their cell sources and adjacent cell components. Therefore, this paper discusses the specific role and mechanism of dif ferent exosomes in different stages of wound healing, and summarizes the current limitations and various view points.


CSTR: 32200.14.cjcb.2024.09.0008