Research Progress on Effects of Exosomes on Multiple Organ Injury in Acute Pancreatitis
LIAN Yuan1, BAI Min1, WANG Zhandong1, ZHANG Yu1, WANG Qiong1, WANG Yongfeng1,2, GUO Chao1,3, SONG Bing1,3*, ZHANG Yanying1,3*
AP (acute pancreatitis) is a clinically common acute abdominal disorder centered on the pan creas that over the course of the disease can induce systemic inflammation that affects multiple organs of the body, including the lungs, intestines, liver, and kidneys. Exosomes are extracellular vesicles produced by cells that carry a variety of active substances and can act as mediators for information exchange between cells. Recent studies have found significant specific changes in plasma exosomes in patients with clinical AP, and relevant basic studies have further revealed the key role of exosomes in AP multiple organ injury. In this paper, the biogenetic process of exo somes and the mechanism of action in AP multiple organ injury were reviewed, so as to further clarify the specific mechanism of exosomes affecting AP multiple organ injury, and provided a new direction for clinical treatment of AP.
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