Research Progress on the Role of TRAPPC Family in Neurological Diseases
WANG Qingyan#, HE Mengze#, WEI Ding, ZHANG Xin, XI Huilin, WU Jiajun, YANG Yanling, LI Youlei*
The TRAPPC (transport protein particle complex) is a multi-subunit complex that is involved in the formation of TRAPP. The TRAPPC family is involved in various key physiological processes such as vesicle transport, autophagy, and glycosylation in the human, and is essential for nervous system homeostasis. With the advancement of the field of molecular biology and the wide application of high-throughput methods such as micro array analysis and next-generation sequencing, the diagnosis of inherited central nervous system diseases has been more accurate, and the important role of TRAPPC family members in neurological diseases has been further clari f ied. This article reviews the effects of the TRAPPC family on the development and function of the nervous system and the research progress of each subunit-related neurological disease, to provide new ideas for the clinical treat ment of related neurological diseases.
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