Progesterone Signaling and Endometrial Function

WANG Haiquan^1#, XIAO Lingyun^2#, SUN Haixiang^1,3*, LI Chaojun^1,2*

(¹Medical School, Nanjing University, Nanjing 210093, China; ²State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing 211166, China; ³Reproductive Medicine Center, Nanjing Drum Tower Hospital, the Affiliated Hospital of Medical School, Nanjing University, Nanjing 210093, China)

Abstract:

Progesterone, a vital steroid hormone in women, plays an integral role in regulating endometrial functions and sustaining pregnancy and reproductive health. Its receptors are categorized into two types: classical receptors, which respond slowly, and non-classical receptors, known for their rapid response. Each type possesses distinct functional isoforms. This review delved into the molecular properties and action mechanisms of the both receptor types, elucidating how they modulated endometrial receptivity, uterine function, and embryo implantation. Moreover, this review also discussed endometrial dysfunctions caused by aberrant progesterone signaling respons es, such as endometriosis, including its pathogenesis and clinical treatment strategies, and provided new insights into the treatment of related reproductive disorders.

CSTR: 32200.14.cjcb.2024.08.0007