Oxidative Modification in Regulating the Activity of Transcription Fact

Abstract: Gene expression is modulated by both physiological signals and environmental stimuli. Recently， reactive oxygen species (ROS) have been suggested as second messengers for several growth factors and cytokines， and have also been shown to rise following cellular insults. ROS can change the redox states of cysteine residues on transcriptional factors， thus playing an important role in regulating the activity of the transcriptional factors through changing the dimer formation， the DNA binding domain， and the motifs of transactivating domain such as zinc fingers. There are lots of studies about the oxidative modification of transcriptional factors relating with proliferation， differentiation apoptosis， such as OxyR， Yap-1， AP-1， NF-κB， p53， Sp1， USF， HIF-1 and C/EBP， which suggests that oxidative modification is a critical way in regulating gene expression. Here we summarize the rationales and a number of examples for regulating transcription factors by oxidative modification.
    

CSTR: 32200.14.cjcb.2009.02.0009