The Potential Role and Mechanism of ApoA-I in the Formation of Tuberculosis
JIA Chenxi, LIU Qimiao, WU Chenjia, WANG Xin, HAO Mingyuan, DONG Li*
Tuberculosis, induced by Mtb (Mycobacterium tuberculosis), is characterized by caseating granuloma formation in response of immunopathological damages. The molecular mechanism underlying the tuberculosis is complex. ApoA-I (Apolipoprotein A1), as a non-glycosylated plasma protein, is anti-inflammatory and antioxidant, able to regulate cholesterol transport, and autophagy, to be involved in various other diseases. The association between ApoA-I and pathogenesis of tuberculosis has attracted extensive attention lately. This article will review the role of ApoA-1 in the tuberculosis development and related biological signaling pathway, which will complete the pathogenesis of tuberculosis and provide a clue for possible strategy of treatment for tuberculosis.
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