Home > Browse Issues > Vol.28 No.6
Function and Mechanism of Sir2 Gene Family
Li-Hui Wang, Wei-Yuan Jin, Yong Chen, Jun-Hui Wang*
College of Life Sciences, ZheJiang University, Hangzhou 310012, China
Abstract: The Sir2 (silence information regulator) gene family is an NAD+ dependent protein deacetylase which is conserved from archaebacteria to humans. In yeast， it has been implicated to play roles in gene silencing， genome stability， longevity and metabolism through histone deacetylase activity during calorie restriction. Mammals have seven homologies of Sir2， namely SIRT1 to SIRT7. The SIRT1 gene has been proven to play a pivotal role in the regulation of DNA repair， metabolism， apoptosis and extend life span. This function is achieved via the interaction between SIRT1 and p53， FOXO3， Ku70 and PGC-1a.
CN
EN