The Roles and Interactions of Heme Oxygenase-1， Dendritic Cell and Regulatory T Cell in Airway Inflammation

Abstract: Chronic airway inflammation is the common pathological process of many kinds of pulmonary diseases， there are several of cells， mediators and cytokines of inflammation those interact and result in various kinds of pathological changes of airway. Heme oxygenase-1 (HO-1)， dendritic cell (DC) and regulatory T cell (Treg) have different mechanisms of action in airway inflammation. HO-1 has the effects of anti-inflammatory and anti-oxidation to protect cells against inflammatory injury， DC can induce persistence of airway inflammation while DC subsets with tolerogenic properties can induce immunotolerance to suppress development of airway inflammation， Treg can play an important role in regulating or suppressing immune responses to maintain immune homeostasis. They can interact in the development of airway inflammation. This article provides a review of the recent studies about their functions and interactions in chronic airway inflammation.
    

CSTR: 32200.14.cjcb.2006.06.0009