Research Progress of RNA Epigenetic Modifications in Regulation of Oogenesis
JIANG Jing#, ZHANG Ming#, LU Jiafeng, HUANG Boxian*
Oogenesis is a pivotal process in reproductive development, involving the development and maturation of oocytes, which significantly impacts female reproductive health and population genetic diversity. Oogenesis entails intricate and precise genetic regulatory mechanisms. RNA (ribonucleic acid) modifications refer to the process of adding chemical groups to RNA molecules, thereby regulating RNA functionality and stability, playing a critical role in reproductive and developmental biology. This review provides an overview and prospects of recent research progress concerning RNA modifications and oogenesis. It primarily elucidates RNA modification regulation of mRNA (messenger RNA) transcription and translation processes, chromatin accessibility, histone modifications, alternative splicing mechanisms, as well as the effects of RNA modifications on oogenesis and embryonic development. This review aims to enhance theoretical research on the regulation of reproductive development through comprehensive RNA epigenetic modifications.
CN
EN