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Chemokines and Chemokine Receptors Induced Lymphocyte Migration and Graft-versus-host Disease
Qi Cao, Yan-Yun Zhang*
Shanghai Institute of Immunology, Shanhai Jiao Tong University School of Medicine, Shanghai 200025, China
Abstract: Graft-versus-host disease (GVHD) is a significant complication of allogeneic bone marrow transplantation (allo-BMT). Acute GVHD is mediated by effector donor T cells， which migrate to lymphoid tissues soon after transplantation， recognize host allo-antigens， and become activated by host antigen presenting cells (APCs). Recent studies on GVHD suggest that activated effector allo-T cells from lymphoid tissues migrate into target organs such as the gastro-intestinal (GI) tract， liver， lung， and skin and cause tissue damage. Moreover， accumulating documents indicated that the migration of effector allo-T cells was mediated by chemokines and chemokine receptors. Involvement of the interaction between chemokine/chemokine receptor would develop an efficient target for GVHD therapy. It would provide a novel insight into developing therapeutic strategy for GVHD.
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