Home > Browse Issues > Vol.28 No.6
Differentiation of Adult Stem Cells into Hepatocytes
Xue-Jun Dong*, Guo-Rong Zhang, Ye Chen1, Li-Xin Xiang1, Ruo-Lang Pan1, Jian-Zhong Shao1
Shaoxing Pepole's Hospital, Shaoxing 312000, China; 1College of Life Science, Zhejiang University, Hangzhou 310058, China
Abstract: The ability of adult stem cells to transdifferentiate into other embryonal layers-derived cells crossing lineage boundaries has now been demonstrated， which plays an important role in understanding the mechanism of interdifferentiation among different embryonal layers cells. And besides， it also provides new cell sources for clinic cell transplantation. Thus， transdifferentiation is currently causing heated debate in the scientific press. This article focuses on the development of adult stem cells transdifferentiate into hepatocytes in recent years. We summarize the isolation， identification， surface makers， biological characteristics and the transdifferentiation mechanism of hepatic oval cells， hepatoblast and extrahepatic stem cells like bone marrow-derived stem cells， pancreatic epithelial progenitor cells， adult neural stem cells， adipose stromal cells and human cord blood-derived stem cells. Their contributions to cell-based therapy for liver diseases have also been anticipated.
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