The Research Progress of Calcium Signaling and Its Inhibitors in Acute Pancreatitis
ZHAO Guiquan1, ZHAO Guiyong2, WANG Yanmei3, WANG Wenbo1, WANG Yingzhen1*
Calcium (Ca2+) signaling plays a crucial role in normal pancreatic physiology, regulating thesecretion of insulin and digestive enzymes. However, in the AP (acute pancreatitis), abnormal intracellular Ca2+ signaling is a central event in its pathogenesis. Under the influence of various triggers, different cell types within pancreatic tissue mediate aberrant intracellular Ca2+ signaling and Ca2+ overload through multiple pathways, leading tocell death and inflammatory responses in pancreatic cells, ultimately accelerating the onset and progression of acutepancreatitis. In recent years, a series of inhibitors targeting various Ca2+ signaling trigger mechanisms have shownsignificant promise in the prevention and treatment of AP, with some drugs advancing to clinical trial stages, offering novel approaches to AP therapy. This article provides a review of the research progress on Ca2+ signaling and itsinhibitors in AP.
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