Research Progress of GPR171
KONG Xue1,2, XIE Xin1,2, DUAN Yanhui1*
GPR171, a recently deorphanized G protein-coupled receptor, is highly expressed in the CNS(central nervous system) and in immune-related tissues. Limited studies have been conducted on the function andactivation mechanisms of GPR171, but GPR171 has been found to play regulatory roles in multiple aspects of thecentral nervous system, including food intake, mood and pain. Additionally, it is also implicated in the immunedefense against tumors and viral infections. Furthermore, GPR171 and GPR83 may modulate receptor functionthrought interaction. This review summarizes the receptor’s currently known characteristics, ligands, and functionsof GPR171, both in the central nervous system and immune system that can be a valuable reference to facilitatefurther research on the functional study of GPR171 as well as the development of targeted drugs.
CN
EN