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Influential Factors of b-catenin in the Classic Wnt/β-catenin Signaling Pathway
Qun Zheng, Li-Hong Xu*
Department of Biochemistry and Genetics, School of Medicine, Zhejiang University, Hangzhou 310058, China
Abstract: Wnt/β-catenin signaling pathway plays an important role in the processes of growth and development of vertebrates. The abnormal activation of the pathway could result from the abnormal change or expression of relevant moleculars， which affects a series of physiological processes， such as the embryonic development and energy metabolism， and even leads to tumorigenesis. However， the alterations of content， distribution and function of β-catenin are the mark of the abnormalities of Wnt pathway. This paper expounds the influential factors of β-catenin， which should enhance the understanding of the relationship between the pathway and the tumor.
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