Use of Organoids in Infectious Disease Modeling
DENG Wenchang, XIE Xiaorui, CHENG Quan, SHEN Shaolei, LIU Li*
Infectious diseases always had a great impact on personal health and social stability. However, traditional animal and 2D (two-dimensional) cell models are difficult to obtain reliable results in pathogens modeling and drug evaluation. Organoids are multicellular systems that develop from stem cells and highly mimic the structure and function of living organisms. It has shown great potential in modeling of infections diseases. This paper highlights the wide application of organoids as infection models in three major fields: viruses, bacteria and protists. In addition, it also discusses the shortcomings of current organoids infection models and looks forward to their future development.
CN
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