Regulatory Mechanism Between Effector Proteins of Legionella pneumophila
KANG Lina1,2, HUANG Shiqing1, CHEN Taotao1,2, OUYANG Songying1,2*
Legionella pneumophila is a Gram-negative bacterium that causes Legionnaires’ disease in humans. The Dot/Icm secretion system is very important to the L. pneumophila pathogenesis, which transports about 330 effector proteins into host cells to manipulate various host cellular processes by modifying cell regulatory factors and inhibiting cell apoptosis, thus promoting its proliferation and infection. In order to avoid unnecessary damage to the host physiology, L. pneumophila has evolved a complicated and precise regulatory mechanism to balance the virulence of L. pneumophila and host homeostasis, so as to ensure the survival of L. pneumophila in the host cell. In recent years, breakthrough has been made in the study of the function and molecular mechanism of Legionella effector proteins, and the mechanism of action between Legionella effector proteins has become a hot topic for further study. In this paper, the pathogenesis and the regulation mechanism between effector proteins of L. pneumophila were reviewed, providing some references for further understanding of the pathogenic mechanism of L. pneumophila.
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