Research Progress on the Senescence of Umbilical Cord Mesenchymal Stem Cells
WU Chunxiu1, ZHANG Jingjing1, WU Jinyi2, JIN Zhigang1 *
hUC-MSCs (human umbilical cord mesenchymal stem cells) are a class of multipotent stem cells derived from human umbilical cord with the capacity of self-renewal, multi-directional differentiation and immune regulation. Compared with other stem cells, hUC-MSCs are advantageous in easy acquisition, isolation, cultivation, and low immunogenicity and tumorigenicity after in vivo implantation. Accordingly, hUC-MSCs have become one of the most important stem cell sources in cell therapy and regenerative medicine. However, in vitro cultured hUC-MSCs are prone to undergo senescence, gradually lose rapid proliferation and multipotency, thereby limiting their clinical application. Here this review focused on the recent progress on the mechanisms underlying the senescence of hUC-MSCs and the corresponding strategies to delay the senescence of hUC-MSCs for a brief summarization and discussion.
CN
EN