Research Progress of High-Mobility Group Protein B1 Mediated Neuroinflammation in Depression
HUA Ruifang, LIU Kerui, WU Beibei, XIE Jingyi, ZHANG Jingjing*
Depression is a common chronic emotional disorder that brings serious economic and social burdens. Neuroinflammation in depression has been progressively advancing. Empirical evidence from clinical and animal models substantiates the close association between elevated levels of pro-inflammatory cytokines and activated microglia, characteristic of neuroinflammatory responses in depression, and the underlying pathogenesis of this disorder. Notably, HMGB1 (high mobility group box 1 protein) is a conserved chromosomal binding protein and an important danger-associated molecular patterns. The release of HMGB1 by immune active cells and necrotic cells in the extracellular space can initiate inflammation in the brain. The advancement in developing HMGB1 antagonists has expanded the potential treatment options for neuropsychiatric diseases. This article focuses on the molecular mechanism of HMGB1 mediated neuroinflammation and its current research status in the pathogenesis and treatment of depression, in order to provide an important theoretical basis for subsequent clinical diagnosis and treatment.
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