Home > Browse Issues > Vol.28 No.6
Progress in Myopodin
Kai Qiu#, Xi-Juan Ying#, Jie Liang, Zi Peng, Gui-Fen Ke, Tao Tao*
School of Life Sciences and Key Laboratory for Cell Biology and Tumor Cell Engineering, the Ministry of Education of China, Xiamen University, Xiamen 361005, China
Abstract: Myopodin is the second member of synaptopodin protein family. It shows no significant homology to any known protein except synaptopodin. Myopodin has two putative classic nuclear localization signals (NLSs). An actin-binding site (aa 410_563) has been found in myopodin. Recent researches show that nuclear import of myopodin is probably related to the progression of the bladder cancer. Patients with preserved nuclear myopodin expression showed a longer survival. Partial or complete deletion of MYOPODIN gene is closely correlated with the prostate cancer. Therefore， myopodin could be used as a potential diagnostic marker for both bladder and prostate cancers in the future.
CN
EN