Molecular Assembly of Motile Cilia

Cilia or flagella are kinds of eukaryotic organelle that protrude from the cell surface, which function in regulation of cell motility and the flow of fluid around cells, or sensation of body. The dysfunction of cilia leads to human ciliopathy. As one of the organelles that found at the earliest, cilia have been being the key point in the study of cell biology. However, during to the large and complexity in structure, the revealing of cilia assembly has been quite difficult. Recently, as the development of cryo-electronic microscopy, the high resolution structures of axoneme components from Chlammydomonas cilia to mammalian sperm flagella have reported by several groups. In this review, the advances of cilia structure and molecular assembly are described, focusing on the assembly mechanism of components that made up cilia axoneme including DMT (doublet microtubule), IDA (inner dynein arm), ODA (outer dynein arm), RS (radial spoke), CP (central pair) and N-DRC (nexin-dynein regulatory complex). This review will provide basis for further understanding of ciliogenesis and functional regulation of cilia.

CSTR: 32200.14.cjcb.2024.01.0013