Home > Browse Issues > Vol.46 No.1
Selective Autophagy Degradation of Protein Aggregates: Aggrephagy
JIA Baihui, LI Huihui, LU Kefeng*
(State Key Laboratory of Biotherapy, Sichuan University West China Hospital, Chengdu 610041, China)
Abstract:
The functional network of cellular proteome is essentially dependent on the maintenance of protein homeostasis through chaperone, ubiquitin proteasome and autophagy. The accumulation of abnormal protein aggregates results in aging and various diseases. The mechanism by which protein aggregates are selectively degraded by autophagy is called aggrephagy. Here the authors introduce the formation of protein aggregates, receptors that recruit substrate aggregates, and the drug development based on aggrephagy.
CN
EN