Autophagosome Biogenesis and Maturation
WU Chunyan1, YANG Yi1, YANG Xia1, LIU Hongyuan1, PANG Yonghao1, TIAN Ruili1, LU Qun1,2*
Autophagy is an evolutionarily conserved lysosome-mediated degradation process in the cell. Autophagosomes are double-membrane vesicles formed during autophagy to engulf a wide range of cytosolic contents and transport them to lysosomes for subsequent degradation, which therefore have essential roles in survival, development, and homeostasis of the cell. Autophagy plays important roles in the physiological process of different organisms and its disruption has been associated with the pathogenesis of various human diseases. Thus, the exploration to the mechanism of autophagosome biogenesis and maturation has a great significance. Here, this article summarizes the autophagosome formation process and the molecular mechanisms underlying autophagosome maturation in multicellular eukaryotes to provide insights into the studies related to autophagy.
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