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Lysosome Related Organelles: Biogenesis and Functions
WANG Qiaochu#*, HAO Zhenhua#, MA Jing#, CHEN Yuanying#, LI Wei*
(Beijing Key Laboratory for Genetics of Birth Defects, Beijing Pediatric Research Institute; MOE Key Laboratory of Major Diseases in Children; Genetics and Birth Defects Control Center, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China)
Abstract:
LROs (lysosome-related organelles) are a class of organelles with specific functions in eukaryotic cells, and their assembly, maturation, and trafficking processes take advantage of the endo-lysosomal pathways. This review summarizes the molecular cellular mechanisms of the structure, function, and biogenesis of four representative LROs (melanosomes, platelet dense granules, large dense-core vesicles, and Weibel-Palade bodies), providing some cues for a better understanding of the pathophysiological roles of LROs.
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