Home > Browse Issues > Vol.46 No.1
Mitochondria and Cell Fate Regulation
DU Cijie1,2,3, CHEN Baodan1,2,3, WANG Mengfei1,2,3, GUO Jingyi4， LIU Xingguo1,2,5*
(1CAS Key Laboratory of Regenerative Biology, Joint School of Life Sciences, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou 510000, China; 2Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, China-New Zealand Joint Laboratory on Biomedicine and Health, CUHK-GIBH Joint Research Laboratory on Stem Cells and Regenerative Medicine, Institute for Stem Cell and Regeneration, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510000, China; 3University of Chinese Academy of Sciences, Beijing 100049, China; 4the Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510799, China; 5Centre for Regenerative Medicine and Health, Hong Kong Institute of Science & Innovation, Chinese Academy of Sciences, Hong Kong 999077, China)
Abstract:
Mitochondria as the central organelle to maintain cell energy production, metabolites regulation and cellular homeostasis regulation which function as the center of cell fate. Besides the nuclear genome, mitochondria possess circular genome called mtDNA (mitochondrial DNA) which participates in the multiple function of mitochondria. This review summarized the function of mitochondria energy production, cell fate regulation stem cells, cell death, cell senescence and disease. Mitochondrial DNA, mitochondrial dynamics, mitochondrial disorder and treatment of mitochondrial disease are mainly elaborated.
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