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The Composition and Main Function of Protein Phosphatase 4
Xiu-Qing Huang, Li-Feng Ning, Zhi-Tao Long, Ling-Ling Sun, Jian-Li Sang*
The Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Science,Beijing Normal University, Beijing 100875, China
Abstract: Protein kinase and phosphatase played equal role in reversible phosphorylation. Recently， focuses transferred from kinase to phosphatase which used to be neglected. Protein phosphatase 4 (PP4 also called protein phosphatase X) is an important member of protein phosphatase 2A family. It formed multiple complexes with different regulatory subunits and participated in many cellular progresses such as centrosome maturation， spicesome assembly， regulation of many pathways and regulation of DNA damage and repair. The paper focuses on the composition， activity regulation and known biological functions of PP4.
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