Research Progress on Ferroptosis in Tumor Diagnosis and Treatment
DENG Yiran1, MA Lifang1,2, WANG Jiayi1,2*
Ferroptosis is a novel way of regulated cell death, which is different from other forms of cell death, such as autophagy, apoptosis, necrosis and pyrodeath. It is characterized by excessive accumulation of lipid peroxides in an iron-dependent manner, resulting in cell membrane rupture and cell death. This unique pattern of cell death is regulated by a variety of intracellular metabolic events, including oxidative stress, iron handling, mitochondrial activity, and metabolism of amino acids, lipids and sugars. Recent studies have shown that ferroptosis is involved in biological process of tumor growth and progression, suggesting that ferroptosis has a great potential in tumor diagnosis and treatment. Ferroptosis inducers could effectively inhibit tumor growth and metastasis, while contribute the therapeutic sensitivity of tumor cells. This review systematically summarizes the molecular regulatory mechanism underlying ferroptosis, and provides its potential application in tumor diagnosis and treatment.
CN
EN