Progress of T Lymphocyte Immunotherapy
LI Yifu1,2, SUN Xuesong1,2, MAI Haiqiang1,2*
As an important component of the tumor microenvironment, T lymphocytes play an extremely important role in the occurrence and development of tumors. However, due to the existence of immune escape mechanisms, cancer cells often disguise themselves, making it difficult for T cells to recognize them, so that they can evade attacks from the human immune system. Therefore, how to awaken T cells in the body to eliminate cancer cells has become a hot topic nowadays. In the past few decades, various new anti-tumor treatment methods based on T lymphocyte immune response have emerged in the field of basic research and clinical application. There are mainly three types of T cell immunotherapy: cytotoxic T lymphocyte therapy, chimeric antigen receptor T cell therapy, and T-cell receptor engineered T cell therapy. This article briefly reviews the mechanisms, techniques, and clinical applications of these three types of T cell immunotherapy.
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