Advances in the Research of cGAS-STING Signaling Pathway in Tumor Development and Targeted Therapy

LIU Tianhao¹^#, ZHENG Mengge^1#, LU Yikai^1#, ZHAO Mengmeng²*, LIU Haipeng¹*

（¹Central Laboratory, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China; ²Research Center of Translational Medicine, Jinan Central Hospital Affiliated to Shandong First Medical University, Jinan 250013, China)

Abstract:

cGAS-STING signaling pathway is an important pathway for recognizing DNA in the cytoplasm and initiating immune response, which can regulate tumor development and anti-tumor immunity through various mechanisms. This article outlines the molecular characteristics and signal transduction of cGAS-STING pathway, discusses its complex mechanisms in regulating tumor development under different conditions and the regulatory factors of cGAS-STING pathway in tumors, and summarizes small-molecule agonists targeting this pathway and their combination medication with other cancer therapies to provide reference for the development of novel tumor clinical therapeutic programs targeting cGAS-STING pathway.

CSTR: 32200.14.cjcb.2023.12.0008