Advances of Oncolytic Viruses in Tumor Therapy

OVs (oncolytic viruses) are promising immunotherapy for tumors, which are DNA viruses and RNA viruses that are naturally or genetically modified to target tumors. Oncolytic viruses have the advantages of tumor targeting, acting as vectors to deliver multiple transgene expressions, inducing immune cell death, and promoting anti-tumor immune responses, and they have a tolerable safety profile. This paper will review the current research status and existing problems of oncolytic viruses in terms of their developmental history, classification, mechanism of action, modification strategies, biomarkers, and clinical applications.

CSTR: 32200.14.cjcb.2023.12.0007