Advances in the Research of the Application of Tumor Markers in the Diagnosis and Treatment of Colorectal Cancer

ZOU Luze¹, QI Qiuchen¹, LI Peilong¹, LI Juan¹, WANG Chuanxin¹, DU Lutao²*

（¹Department of Clinical Laboratory, The Second Hospital Shandong University, Jinan 250033; ²Department of Clinical Laboratory, Qilu Hospital, Shandong University, Shandong Provincial Key Laboratory of Laboratory Medicine Innovation Technology, Jinan 250012, China)

Abstract:

CRC (colorectal cancer) is the third most common malignancy and one of the leading causes of cancer-related deaths worldwide. In recent years, with the development of various emerging omics sequencing technologies and artificial intelligence, the application of tumor markers in clinical oncology has been expanding. Novel biomarkers based on DNA methylation, non-coding RNA, circulating tumor cells, gastrointestinal microbiome and metabolites have gradually become the key directions in cancer diagnosis and treatment research, and play an important guiding role in the early screening and diagnosis of CRC, efficacy testing and prognosis evaluation. This article reviews the application and progress of commonly used CRC tumor biomarkers and new tumor biomarkers in the diagnosis and treatment of CRC, and discusses the potential application prospects of big data and artificial intelligence in the diagnosis and treatment of tumors, in order to provide a reference for the research on the diagnosis and treatment of CRC.

CSTR: 32200.14.cjcb.2023.12.0004