Applications of Gene Editing Technologies in Cancer Therapy
XIONG Xiangyu, BEI Jinxin*
The development of gene editing technologies, stemming from engineered or bacterial nucleases, has enabled precise targeting and modification of genomic sequences across a majority of eukaryotic cells. This review provides a comprehensive overview of the evolution and advancements of three paramount gene editing systems: ZFNs (zinc finger nucleases), TALENs (transcription activator-like effector nucleases), and CRISPR/Cas (clustered regularly interspaced short palindromic repeat and CRISPR-associated proteins). This discourse further elucidates their potential applications in cancer therapeutics and highlights the challenges encountered in integrating these gene editing modalities into clinical therapy practice.
CN
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