The Molecular Mechanism underlying the Initiationof Primary Cilia Biogenesis
WANG Qiaoling1, WU Zhimao2, WAN Didi1*, WEI Qing2*
Primary cilia are microtubule-based membrane protrusions, locate on the surface of cells andare widely present in eukaryotic organisms. As the “antennae” of cells, primary cilia participate in the transduction of various important intracellular signaling and play a crucial role in the development, differentiation, andhomeostasis maintenance of animal tissues and organs. Therefore, defects in ciliary structure and function lead tovarious organ pathologies and trigger a series of human genetic diseases. Cilia arise from the top of the mothercentriole, but the molecular mechanism of ciliogenesis initiation is still not well understood at present. The initiation of ciliogenesis primarily involves basal body docking, removal of the centriole cap protein CP110, andformation of the ciliary bud. This review aims to summarize recent advancements in these three areas, offeringreferences to enhance the comprehension of the molecular mechanisms underlying ciliogenesis initiation.
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